An invention of thermo-responsive polymer surface, yielding cell sheet based regenerative therapies in cardiology and ophthalmology
نویسندگان
چکیده
1 Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Japan, 2 Frontier Lifeline Hospitals, Chennai , India, 3 Stem Cell Facility, All India Institute of Medical Sciences (AIIMS), New Delhi, India, 4 SRM Institute for Medical Sciences, Chennai India, India, 5 The Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, India, 6 Yamanashi UniversitySchool of Medicine, Chuo, Japan
منابع مشابه
Temperature-Responsive Polymer Modified Surface for Cell Sheet Engineering
In the past two decades, as a novel approach for tissue engineering, cell sheet engineering has been proposed by our laboratory. Poly(N-isopropylacrylamide) (PIPAAm), which is a well-known temperature-responsive polymer, has been grafted on tissue culture polystyrene (TCPS) surfaces through an electron beam irradiated polymerization. At 37 °C, where the PIPAAm modified surface is hydrophobic, c...
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متن کاملLipidic composite vesicles based on poly(NIPAM), chitosan or hyaluronan: behaviour under stresses
Giant Unilamellar Vesicles (GUVs) consisting in self-closed lipid bilayers of 0.5-100 µm diameter are considered as oversimplified models of cells because of their biological membrane and micrometric size while Large Unilamellar Vesicles (LUVs) of 100-500 nm diameter have applications in drug delivery. To improve structural and mechanical properties of these vesicles, we have developed two cate...
متن کاملRecent development of temperature-responsive surfaces and their application for cell sheet engineering.
Cell sheet engineering, which fabricates sheet-like tissues without biodegradable scaffolds, has been proposed as a novel approach for tissue engineering. Cells have been cultured and proliferate to confluence on a temperature-responsive cell culture surface at 37°C. By decreasing temperature to 20°C, an intact cell sheet can be harvested from the culture surface without enzymatic treatment. Th...
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At present, cardiac diseases are a major cause of morbidity and mortality in the world. Recently, a cell-based regenerative medicine has appeared as one of the most potential and promising therapies for improving cardiac diseases. As a new generational cell-based regenerative therapy, tissue engineering is focused. Our laboratory has originally developed cell sheet-based scaffold-free tissue en...
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